London — False and misleading information supercharged with cutting-edge artificial intelligence that threatens to erode democracy and polarize society is the top immediate risk to the global economy, the World Economic Forum said in a report Wednesday. In its latest Global Risks Report, the organization also said an array of environmental risks pose the biggest threats in the longer term. The report was released ahead of the annual elite gathering of CEOs and world leaders in the Swiss ski resort town of Davos and is based on a survey of nearly 1,500 experts, industry leaders and policymakers. The report listed misinformation and disinformation as the most severe risk over the next two years, highlighting how rapid advances in technology also are creating new problems or making existing ones worse. The authors worry that the boom in generative AI chatbots like ChatGPT means that creating sophisticated synthetic content that can be used to manipulate groups of people won't be limited any longer to those with specialized skills. AI is set to be a hot topic next week at the Davos meetings, which are expected to be attended by tech company bosses including OpenAI CEO Sam Altman, Microsoft CEO Satya Nadella and AI industry players like Meta's chief AI scientist, Yann LeCun. AI-powered misinformation and disinformation is emerging as a risk just as a billions of people in a slew of countries, including large economies like the United States, Britain, Indonesia, India, Mexico, and Pakistan, are set to head to the polls this year and next, the report said. "You can leverage AI to do deepfakes and to really impact large groups, which really drives misinformation," said Carolina Klint, a risk management leader at Marsh, whose parent company Marsh McLennan co-authored the report with Zurich Insurance Group. "Societies could become further polarized" as people find it harder to verify facts, she said. Fake information also could be used to fuel questions about the legitimacy of elected governments, "which means that democratic processes could be eroded, and it would also drive societal polarization even further," Klint said. The rise of AI brings a host of other risks, she said. It can empower "malicious actors" by making it easier to carry out cyberattacks, such as by automating phishing attempts or creating advanced malware. With AI, "you don't need to be the sharpest tool in the shed to be a malicious actor," Klint said. It can even poison data that is scraped off the internet to train other AI systems, which is "incredibly difficult to reverse" and could result in further embedding biases into AI models, she said. The other big global concern for respondents of the risk survey centered around climate change. Following disinformation and misinformation, extreme weather is the second-most-pressing short-term risk. In the long term — defined as 10 years — extreme weather was described as the No. 1 threat, followed by four other environmental-related risks: critical change to Earth systems; biodiversity loss and ecosystem collapse; and natural resource shortages. "We could be pushed past that irreversible climate change tipping point" over the next decade as the Earth's systems undergo long-term changes, Klint said.

WASHINGTON — A recent cyber kidnapping incident involving a Chinese exchange student in Utah appears to be part of an international pattern in which unknown perpetrators, often masquerading as Chinese police or government officials, target Chinese students around the world and extort their families for upwards of tens of thousands of dollars. In late December, 17-year-old Chinese student Kai Zhuang was reported missing near Salt Lake City, only to be found days later alone and freezing in a tent in the mountains. Authorities have said the case was part of an apparent cyber kidnapping scheme to scam his family in China out of $80,000. Cyber kidnapping is when perpetrators pretend to have abducted someone to coerce their family into paying a ransom. “At the heart of it are the heartstrings of the victim, who is told to go run and hide, and the heartstrings of the people who think their loved one is actually in the possession of kidnappers,” said Theresa Payton, CEO of cybersecurity company Fortalice Solutions. “Virtual kidnapping is, at its very root, manipulative. It is coercive. It is emotionally draining and complex,” said Payton, who is based in Charlotte, North Carolina. On January 3, just days after Kai Zhuang was found, the FBI issued a warning about criminals impersonating Chinese police officers to defraud Chinese people based in the United States, especially Chinese students. Around the world VOA has learned that the cyber scams aren’t targeting only Chinese students studying in the United States. Over the past year, Chinese students studying abroad in Australia, Canada, the United Kingdom and Japan have also been targeted by cyber kidnapping scams and other cybercrime schemes, VOA found. In these countries, the perpetrators also often pretended to be Chinese police officers or government officials. Cybersecurity experts said this tactic indicates criminals are leveraging China’s authoritarian system, in which deference to and fear of the police are the norm, to their advantage. “Chinese people are naturally afraid of the police,” said Han Jiang Du Diao Seng, a pharmacist based in the United States who runs accounts on YouTube and Weibo that are popular among Chinese exchange students. Han Jiang Du Diao Seng has helped four Chinese students caught up in cyber kidnapping scams, he said. In his experience, he said, scammers posing as government officials tend to approach Chinese students and first ask if they recently received money from their family in China. If the student says yes, he said, the scammer either claims the money was transferred illegally or that their family is being targeted by criminals, before requiring the student to halt contact with their family during an investigation — all of which is a ploy to then extort money from the family. Left their homes In the incidents Han Jiang Du Diao Seng worked on, he said, the criminals coerced all the students to leave where they lived and go stay at a hotel, which helped convince their parents that they were actually kidnapped. He said that these criminals may be taking advantage of the fact that Chinese parents may be less likely to report the incidents to American police — in part due to language barriers but also due to general distrust among Chinese people of the American police. Chinese state media regularly depict American police as violent and irresponsible. “You have a fear of government involvement and law enforcement involvement because the relationship to the government is different,” cybersecurity expert Joseph Steinberg said, referring to people from authoritarian countries such as China. There is no clear data on the number of cyber kidnapping cases in the United States or around the world, cybersecurity experts told VOA, but incidents seem to be rising. Technological advancements, particularly with artificial intelligence, risk making the schemes even easier to perpetrate, they said. There are different tiers of sophistication in these cybercrime syndicates, according to Payton. At the lower end, perpetrators may use an auto dialer to target random people in hopes of getting a few hundred dollars, she said. More sophisticated schemes At the upper end, perpetrators use artificial intelligence algorithms to identify targets and deepfake technology to create photos and audio intended to make victims believe their loved one has actually been kidnapped, Payton said. “You do not actually have to be technically minded to get into this type of crime. You just have to be a twisted, evil individual,” she said. AI advancements mean perpetrators don’t even need to speak the same language as their victims, according to Steinberg, who is based in New York City. “AI is only going to get better, and that means that the attacks will only be more and more realistic,” he told VOA. Some cybercriminals are just after a quick buck, Steinberg said. “But you have some that are after the big dollars and will spend the time to do the research,” he said. That may help explain why Chinese exchange students apparently are being specifically targeted. Payton said that given the complex relationship between the Chinese government and its citizens, as well as other factors such as culture, history and economics, “it is conceivable that global criminal syndicates engaging in such activities as virtual kidnapping may perceive young Chinese adults studying abroad as more susceptible to fall prey to this crime,” Payton said. In Canada in February 2023, regional police said Chinese students had been swindled out of hundreds of thousands of dollars by scammers claiming to be Chinese government officials. Similar incidents have played out in Australia, Japan and the United Kingdom. It is not clear whether the perpetrators of any of these crimes are linked in any way. The investigation into the recent Utah incident is ongoing, and it is not clear whether the perpetrators imitated Chinese officials. China’s embassy in Washington did not respond to that question when VOA reached out for comment. Warnings from embassies and police The embassy did urge Chinese citizens in the U.S., especially those studying in the country, to boost safety awareness, take necessary precautions, and stay vigilant against "virtual kidnapping" and other forms of telecom and online fraud. In the span of two months in Japan last summer, at least six Chinese students were targeted in cyber kidnapping schemes, local police said. The Chinese Embassy in Tokyo issued a warning about the scams in August, urging Chinese citizens in the country to “be wary” and “vigilant.” Local British police issued a warning about cyber scams targeting Chinese students in September, and the Australian government released a similar warning a month later. “These criminal syndicates demonstrate a profound understanding of human behavior, potentially leveraging fear tactics to manipulate individuals into compliance and their families into making payments. They are targeting all demographics, but the trend appears to indicate they favor targeting Chinese exchange students studying abroad,” Payton said. To avoid falling victim to these kinds of schemes, cybersecurity experts recommended families set up a password to verify one another’s identity over the phone during these kinds of scenarios. “The cyber kidnapping scam very much can happen to anybody, and that’s what people need to be aware of,” Steinberg said.

washington — The United States is pushing back its planned return of astronauts to the surface of the Moon from 2025 to 2026, NASA Administrator Bill Nelson said Tuesday. Artemis, named after the sister of Apollo in Greek mythology, was officially announced in 2017 as part of the US space agency's plans to establish a sustained presence on Earth's nearest space neighbor, and apply lessons learned there for a future mission to Mars. Its first mission, an uncrewed test flight to the Moon and back called Artemis 1, took place in 2022, after several postponements. Artemis 2, involving a crew that doesn't land on the surface, has been postponed from later this year to September 2025, Nelson told reporters. Artemis 3, in which the first woman and first person of color are to set foot on lunar soil at the Moon's south pole, should now take place in September 2026. "Safety is our top priority, and to give Artemis teams more time to work through the challenges," said Nelson. NASA is also looking to build a lunar space station called Gateway where spacecraft will dock during later missions. Elon Musk's SpaceX has won the contract for a landing system for Artemis 3 based on a version of its prototype Starship rocket, which remains far from ready. Both of its orbital tests have ended in explosions. Delays to Starship have knock-on effects because the spacesuit contractor needs to know how the suits will interface with the spacecraft, and simulators need to be built for astronauts to learn its systems. And the Artemis 1 mission itself revealed technical issues, such as the heat shield on the Orion crew capsule eroded in an unexpected way, and the ground structure used to launch the giant SLS rocket sustained more damage than expected. As of March 2023, NASA has agreed to pay approximately $40 billion to hundreds of contractors in support of Artemis, the same watchdog found. A key difference between the 20th-century Apollo missions and the Artemis era is the increasing role of commercial partnerships, part of a broader strategy to involve the private companies in space exploration to reduce costs and to make space more accessible.

Washington — Meta on Tuesday said it was tightening up content restrictions for teens on Instagram and Facebook as it faces increased scrutiny that its platforms are harmful for young people.  The changes come months after dozens of U.S. states accused Meta of damaging the mental health of children and teens, and misleading users about the safety of its platforms.  In a blog post, the company run by Mark Zuckerberg said it will now "restrict teens from seeing certain types of content across Facebook and Instagram even if it's from friends or people they follow."  This type of content would include content that discusses suicide or self-harm, as well as nudity or mentions of restricted goods, the company added.  Restricted goods on Instagram include tobacco products and weapons as well as alcohol, contraception, cosmetic procedures and weight loss programs, according to its website.  In addition, teens will now be defaulted into the most restricted settings on Instagram and Facebook, a policy that was in place for new users and that now will be expanded to existing users.  This will "make it more difficult for people to come across potentially sensitive content or accounts in places like Search and Explore," the company said.  Meta also said that it will expand its policy of hiding results to searches related to suicide and self harm to include more terms. Leaked internal research from Meta, including by the Wall Street Journal and whistle-blower Frances Haugen, has shown that the company was long aware of dangers its platforms have on the mental health for young people. On the platforms, teens are defined as being under eighteen, based on the date of birth they give when signing up. 

Cape Canaveral, Florida — The first U.S. lunar lander in more than 50 years rocketed toward the moon Monday, launching private companies on a space race to make deliveries for NASA and other customers. Astrobotic Technology's lander caught a ride on a brand new rocket, United Launch Alliance’s Vulcan. The Vulcan streaked through the Florida predawn sky, putting the spacecraft on a roundabout route to the moon that should culminate with an attempted landing on Feb. 23. The Pittsburgh company aims to be the first private business to successfully land on the moon, something only four countries have accomplished. But a Houston company also has a lander ready to fly, and could beat it to the lunar surface, taking a more direct path. “First to launch. First to land is TBD" — to be determined, said Astrobotic chief executive John Thornton. NASA gave the two companies millions to build and fly their own lunar landers. The space agency wants the privately owned landers to scope out the place before astronauts arrive while delivering NASA tech and science experiments as well as odds and ends for other customers. Astrobotic's contract for the Peregrine lander: $108 million. The last time the U.S. launched a moon-landing mission was in December 1972. Apollo 17’s Gene Cernan and Harrison Schmitt became the 11th and 12th men to walk on the moon, closing out an era that has remained NASA’s pinnacle. The space agency’s new Artemis program — named after the twin sister of Apollo in Greek mythology — looks to return astronauts to the moon’s surface within the next few years. First will be a lunar fly-around with four astronauts, possibly before the end of the year. Highlighting Monday's moonshot was the long-delayed initial test flight of the Vulcan rocket from Cape Canaveral Space Force Station. The 61-meter rocket is essentially an upgraded version of ULA’s hugely successful workhorse Atlas V, which is being phased out along with the company’s Delta IV. Jeff Bezos' rocket company, Blue Origin, provided the Vulcan's two main engines. The Soviet Union and the U.S. racked up a string of successful moon landings in the 1960s and 70s, before putting touchdowns on pause. China joined the elite club in 2013 and India in 2023. But last year also saw landers from Russia and a private Japanese company slam into the moon. An Israeli nonprofit crashed in 2019. Next month, SpaceX will provide the lift for a lander from Intuitive Machines. The Nova-C lander's more direct one-week route could see both spacecraft attempting to land within days or even hours of one another. The hourlong descent to the lunar surface — by far the biggest challenge — will be “exciting, nail-biting, terrifying all at once,” said Thornton. Besides flying experiments for NASA, Astrobotic drummed up its own freight business, packing the 1.9-meter-tall Peregrine lander with everything from a chip of rock from Mount Everest and toy-size cars from Mexico that will catapult to the lunar surface and cruise around, to the ashes and DNA of deceased space enthusiasts, including “Star Trek” creator Gene Roddenberry and science fiction writer Arthur C. Clarke. The Navajo Nation recently sought to have the launch delayed because of the human remains, saying it would be a “profound desecration” of a celestial body revered by Native Americans. Thornton said the December objections came too late but promised to try to find “a good path forward” with the Navajo for future missions. One of the spaceflight memorial companies that bought room on the lander, Celestis, said in a statement that no single culture or religion owns the moon and should not be able to veto a mission. More remains are on the rocket’s upper stage, which, once free of the lander, will indefinitely circle the sun as far out as Mars. Cargo fares for Peregrine ranged from a few hundred dollars to $1.2 million per kilogram, not nearly enough for Astrobotic to break even. But for this first flight, that's not the point, according to Thornton. “A lot of people’s dreams and hopes are riding on this,” he said.

Cape Canaveral, Florida — The first American spacecraft to attempt to land on the Moon in more than half a century is poised to blast off early Monday — but this time, private industry is leading the charge.   A brand-new rocket, United Launch Alliance's Vulcan Centaur, should lift off from Cape Canaveral Space Force Station at 2:18 a.m. (7:18 GMT) for its maiden voyage, carrying Astrobotic's Peregrine Lunar Lander. The weather so far appears favorable. If all goes to plan, Peregrine will touch down on a mid-latitude region of the Moon called Sinus Viscositatis, or Bay of Stickiness, on February 23. "Leading America back to the surface of the Moon for the first time since Apollo is a momentous honor," Pittsburgh-based Astrobotic's CEO John Thornton said ahead of the launch. Until now, a soft landing on Earth's nearest celestial neighbor has only been accomplished by a handful of national space agencies: the Soviet Union was first, in 1966, followed by the United States, which is still the only country to put people on the Moon.   China has successfully landed three times over the past decade, while India was the most recent to achieve the feat on its second attempt, last year. Now, the United States is turning to the commercial sector to stimulate a broader lunar economy and ship its own hardware at a fraction of the cost, under the Commercial Lunar Payload Services (CLPS) program. A challenging task   The space agency has paid Astrobotic more than $100 million for the task, while another contracted company, Houston-based Intuitive Machines, is looking to launch in February and land near the south pole. "We think that it's going to allow... more cost effective and more rapidly accomplished trips to the lunar surface to prepare for Artemis," said NASA's Joel Kearns, deputy associate administrator for exploration. Artemis is the NASA-led program to return astronauts to the Moon later this decade, in preparation for future missions to Mars. Controlled touchdown on the Moon is a challenging undertaking, with roughly half of all attempts ending in failure. Absent an atmosphere that would allow the use of parachutes, a spacecraft must navigate through treacherous terrain using only its thrusters to slow descent. Private missions by Israel and Japan, as well as a recent attempt by the Russian space agency have all ended in failure — though the Japanese Space Agency is targeting mid-January for the touchdown of its SLIM lander launched last September. Making matters more fraught is the fact it is the first launch for ULA's Vulcan, although the company boasts it has a 100 percent success rate in its more than 150 prior launches. ULA's new rocket is planned to have reusable first stage booster engines, which the company, a joint venture between Lockheed Martin and Boeing, expects will help it achieve cost savings. Science instruments, human remains On board Peregrine are a suite of scientific instruments that will probe radiation and surface composition, helping to pave the way for the return of astronauts. But it also contains more colorful cargo, including a shoebox-sized rover built by Carnegie Mellon University, a physical Bitcoin, and, somewhat controversially, cremated remains and DNA, including those of Star Trek creator Gene Roddenberry, legendary sci-fi author and scientist Arthur C. Clarke, and a dog. The Navajo Nation, America's largest Indigenous tribe, has said sending these to the Moon desecrates a body that is sacred to their culture and have pleaded for the cargo's removal. Though they were granted a last-ditch meeting with the White House, NASA and other officials, their objections have been ignored.   The Vulcan rocket's upper stage, which will circle the Sun after it deploys the lander, is meanwhile carrying more late cast members of Star Trek, as well as hair samples of presidents George Washington, Dwight D. Eisenhower and John F. Kennedy.  

New Delhi — India has achieved another milestone in space exploration by successfully placing a spacecraft in an orbit from which it will study the sun for five years. India joined a select group of nations already studying the sun four months after it became the first country to land an unmanned spacecraft on the moon's southern polar region, cementing its reputation as a nation that is emerging on the frontlines of space exploration. The Indian Space Research Organization said that the space observatory, Aditya L-1, reached the position from which it can monitor the sun’s outer layer and send data back to Earth on Saturday. The spacecraft, which was launched September 2, took four months to reach its destination. "The orbit of Aditya-L1 spacecraft is a periodic Halo orbit which is located roughly 1.5 million km [kilometers] from earth," according to an ISRO statement. Aditya-L1 is named after the Hindu god of the sun, called Aditya in Sanskrit. "L1" refers to Lagrange point 1, the location in space between the sun and Earth, where the satellite has been parked. "This demonstrates India’s capability to travel over a million kilometers away from the Earth’s orbit. It is a capability that very few countries have and India is the first in Asia to do so," according to Chaitanya Giri, associate professor of environmental sciences at Flame University in Pune. "The ability to maintain deep space communication with a spacecraft that has traveled so far and sustain a mission for a long period is also significant." The Indian mission is scheduled to study the sun for five years. The "Lagrange 1" point, where the spacecraft has been positioned provides an uninterrupted view of the sun, even during eclipses. The major focus of the mission is to gain a better understanding of space weather, variations in the environment in space between the Earth and the sun, which is crucial for protecting satellites and other spacecraft, according to space scientists. "It is vital to understand space weather at a time when there are thousands of satellites in space," Ajay Lele, space scientist and former senior fellow at the Manohar Parrikar Institute of Defense Studies and Analyses in New Delhi, said. "Space weather is about disturbances that happen on the sun such as solar winds, solar flares and coronal mass ejections. These three components need to be studied," he said. Aditya-L1 is expected to be able to give warnings about space storms that can have an impact on Earth, occasionally affecting the operation of satellites and radio communications. The spacecraft is equipped with seven scientific instruments to study solar wind particles and magnetic fields. Solar observatory missions have been launched so far by the U.S. space agency NASA, the European space agency, Japan and China. India’s space program, which began in the 1960s, has gained prominence under Prime Minister Narendra Modi — it is seen as part of his efforts to promote India’s global stature. "India creates yet another landmark. It is a testament to the relentless dedication of our scientists in realizing among the most complex and intricate space missions," Modi said in a post on X, formerly known as Twitter, on Saturday. Other major missions planned by the Indian space agency include a manned mission to space that is due to be launched this year and an interplanetary mission to Mars. Besides scientific space explorations such as these, India is also looking to enhance its military capabilities in space, according to experts. The first signal that it is giving a military profile to its space program came in 2019 when it conducted an anti-satellite weapon test to demonstrate that it could shoot down satellites in space — a capability that only the United States, China and Russia have. India has plans to develop 50 new satellites based on artificial intelligence technology in the next five years to beef up the country’s border surveillance and enhance its "geo-intelligence" capabilities, Indian Space Research Organization (ISRO) chairman S. Somanath said last month. Enhancing surveillance capabilities from space from a military perspective is key for India, according to experts. Its concerns center both on its Himalayan borders with China, where disputed borders between the two have sparked military tensions, and on the Indian Ocean region, where China has been increasing its influence.

LONDON — U.K. police have opened a fraud investigation into Britain's Post Office over a miscarriage of justice that saw hundreds of postmasters wrongfully accused of stealing money when a faulty computer system was to blame. The Metropolitan Police force said late Friday that it is investigating "potential fraud offences arising out of these prosecutions," relating to money the Post Office received "as a result of prosecutions or civil actions" against accused postal workers. Police also are investigating potential offenses of perjury and perverting the course of justice over investigations and prosecutions carried out by the Post Office. Between 1999 and 2015, more than 700 post office branch managers were accused of theft or fraud because computers wrongly showed that money was missing. Many were financially ruined after being forced to pay large sums to the company, and some were convicted and sent to prison. Several killed themselves. The real culprit was a defective computer accounting system called Horizon, supplied by the Japanese technology firm Fujitsu, that was installed in local Post Office branches in 1999. The Post Office maintained for years that data from Horizon was reliable and accused branch managers of dishonesty when the system showed money was missing. After years of campaigning by victims and their lawyers, the Court of Appeal quashed 39 of the convictions in 2021. A judge said the Post Office "knew there were serious issues about the reliability" of Horizon and had committed "egregious" failures of investigation and disclosure. A total of 93 of the postal workers have now had their convictions overturned, according to the Post Office. But many others have yet to be exonerated, and only 30 have agreed to "full and final" compensation payments. A public inquiry into the scandal has been underway since 2022. So far, no one from the publicly owned Post Office or other companies involved has been arrested or faced criminal charges. Lee Castleton, a former branch manager who went bankrupt after being pursued by the Post Office for missing funds, said his family was ostracized in their hometown of Bridlington in northern England. He said his daughter was bullied because people thought "her father was a thief, and he'd take money from old people." He said victims wanted those responsible to be named. "It's about accountability," Castleton told Times Radio on Saturday. "Let's see who made those decisions and made this happen." The long-simmering scandal stirred new outrage with the broadcast this week of a TV docudrama, Mr. Bates vs the Post Office. It charted a two-decade battle by branch manager Alan Bates, played by Toby Jones, to expose the truth and clear the wronged postal workers. Post Office Chief Executive Nick Read, appointed after the scandal, welcomed the TV series and said he hoped it would "raise further awareness and encourage anyone affected who has not yet come forward to seek the redress and compensation they deserve." A lawyer for some of the postal workers said 50 new potential victims had approached lawyers since the show aired on the ITV network. "The drama has elevated public awareness to a whole new level," attorney Neil Hudgell said. "The British public and their overwhelming sympathy for the plight of these poor people has given some the strength to finally come forward. Those numbers increase by the day, but there are so many more out there."

The Consumer Electronics Show, better known as CES, is back in Las Vegas [January 9 – 12] with more than 3,500 companies from around the globe showcasing the latest developments in artificial intelligence, health care, transportation and much more. VOA’s Julie Taboh gives us a preview. Video edit: Adam Greenbaum. Tina Trinh contributed to this report

washington — Scientists have found a way to help Alzheimer's drugs seep inside the brain faster — by temporarily breaching its protective shield. The novel experiment was a first attempt in just three patients. But in spots in the brain where the new technology took aim, it enhanced removal of Alzheimer's trademark brain-clogging plaque, researchers reported Wednesday. "Our goal is to give patients a head start," by boosting some new Alzheimer's treatments that take a long time to work, said Dr. Ali Rezai of West Virginia University's Rockefeller Neuroscience Institute, who led the study. At issue is what's called the blood-brain barrier, a protective lining in blood vessels that prevents germs and other damaging substances from leaching into the brain from the bloodstream. But it also can block drugs for Alzheimer's, tumors and other neurologic diseases, requiring higher doses for longer periods for enough to reach their target inside the brain. Now scientists are using a technology called focused ultrasound to jiggle temporary openings in that shield. They inject microscopic bubbles into the bloodstream. Next, they beam sound waves through a helmetlike device to a precise brain area. The pulses of energy vibrate the microbubbles, which loosen gaps in the barrier enough for medications to slip in. Prior small studies have found the technology can safely poke tiny holes that seal up in 48 hours. Now Rezai's team has gone a step further — administering an Alzheimer's drug at the same time. Some new Alzheimer's drugs, on the market or in the pipeline, promise to modestly slow worsening of the mind-robbing disease. They're designed to clear away a sticky protein called beta-amyloid that builds up in certain brain regions. But they require IV infusions every few weeks for at least 18 months. "Why not try to clear the plaques within a few months?" Rezai said, his rationale for the proof-of-concept study. 3 patients, 1 drug, 6 months His team gave three patients with mild Alzheimer's monthly doses of one such drug, Aduhelm, for six months. Right after each IV, researchers aimed the focused ultrasound on a specific amyloid-clogged part of each patient's brain, opening the blood brain-barrier so more of that day's dose might enter that spot. PET scans show patients' amyloid levels before and after the six months of medication. There was about 32% greater plaque reduction in spots where the blood-brain barrier was breached compared to the same region on the brain's opposite side, researchers reported in the New England Journal of Medicine. This pilot study is elegant but too tiny to draw any conclusions, cautioned Dr. Eliezer Masliah of the National Institute on Aging. Still, "it's very exciting, compelling data," added Masliah, who wasn't involved with the research. "It opens the door for more extensive, larger studies, definitely." More testing on horizon Rezai is about to begin another small test of a similar but better proven drug named Leqembi. Eventually, large studies would be needed to tell if combining focused ultrasound with Alzheimer's drugs makes a real difference for patients. Masliah said it's also important to closely check whether speedier plaque reduction might increase the risk of a rare but worrisome side effect of these new drugs — bleeding and swelling in the brain. Alzheimer's isn't the only target. Other researchers are testing if breaching the blood-brain barrier could allow more chemotherapy to reach brain tumors, and ways to target other diseases.